Interactions and Feedbacks in E-Cadherin Transcriptional Regulation

Epithelial tissues rely on the adhesion between participating cells to retain their integrity. The transmembrane protein E-cadherin is major that mediates homophilic neighbouring and is, therefore, one of critical components for epithelial downregulation has been described extensively as a prerequisite epithelial-to-mesenchymal transition hallmark in many types cancer. Due this clinical importance, research mostly focused understanding mechanisms leading transcriptional repression molecule. However, recent years it become apparent re-expression step progression cancers during metastasis. Here, we review currently known molecular activation inhibition highlight complex interactions individual mechanisms. We then propose an additional mechanism, whereby competition complexes heterochromatin protein-1 binding STAT92E fine-tunes levels expression Drosophila but also regulates other genes promoting robustness. base our hypothesis both existing literature experimental evidence suggest such feedback cell surface nucleus presents powerful paradigm resilience.